All formulas
Head to head
Similac 360 Total Care vs Up&Up Premium
In independent testing, Up&Up Premium showed lower heavy-metal levels overall (purity 96 vs 76). The full lab numbers, metal by metal:
| Purity score | 76B | 96A |
| Lead ppb | 2.8 | — |
| Total Arsenic ppb | 3.2 | — |
| Cadmium ppb | 1.4 | — |
| Aluminum ppb | 653 | 191 |
| Price | $1.14/oz | $0.72/oz |
| Est. cost at 28 oz/day | $4.94/day | $3.14/day |
| Origin | US | US |
| Base | Cow's milk | Cow's milk |
| Buy | Buy |
Similac360 Total Care
Up&UpPremium
Lab data: Consumer Reports independent testing, March 2025. Purity scores are relative to the tested cohort — methodology. Not medical advice; consult your pediatrician.